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You are here:Home » Antibodies » Antibodies-Calnexin » Anti -Calnexin - ER Marker

Anti -Calnexin - ER Marker


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Clone Host Grade Applications
Monoclonal Mouse Ascites B IP IC IF
Calnexin, also referred to as IP90, p88 and p90, is an ~90kD integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins. Studies indicate that calnexin associates with the major histocompatability complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP78 and GRP94 and protein disulfide isomerase.
Catalog #C1035-26E
ApplicationsSuitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:4000
Immunocytochemistry: 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No8J486
ConcentrationNot Determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
ImmunogenFocus human hepatoma cell lysate. Cellular Localization: Endoplasmic reticulum.
SpecificityRecognizes human calnexin-ER marker at ~90kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCANX, CNX, FLJ26570, Histocompatibility complex class I antigen binding protein p88, IP90

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