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You are here:Home » Antibodies » Abs to Calmodulin » Anti -CaM Kinase IV (Calmodulin-Dependent Protein Kinase IV, CAMKIV)

Anti -CaM Kinase IV (Calmodulin-Dependent Protein Kinase IV, CAMKIV)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
CaM kinase IV (CaMKIV), in a calcium and calmodulin dependent manner, is implicated in phosphorylating numerous transcription factors including the CCAAT enhancer binding protein (C / EBP), serum response factor (SRF), and cyclic AMP response element binding protein (CBP). The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.
Catalog #C1036-85G
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5ug/ml detects an ~55kD protein representing CaMKIV in Hela cell lysate.
Immunohistochemistry (frozen): 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormPBS, 1 mg/ml BSA and 0.05% sodium azide
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa127-143, V(127)EKGYYSERDAADAVKQ(143)C from mouse CaMKIV.
This sequence is 94% conserved in rat and human CaMKIV.
SpecificityRecognizes mouse Cam Kinase IV at ~55kD.
Species CrossreactivityHuman, rat, canine, primate, arabidopsis, Xenopus oocyte samples and plant.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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