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You are here:Home » Antibodies » Abs to Cardiotin » Anti -Cardiotin

Anti -Cardiotin

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH
Cardiotin is a recently discovered, high molecular weight protein complex (300kD) located in the mitochondrial membrane. The cardiotin structure exists of subunits of 60kD and 100kD. Both subunits contain the same amino-terminal 14 amino-acid sequence, showing high homology to human skeletal muscle a-actinin, suggesting that the tetrameric configuration of the cardiotin protein structure is a transmembrane complex with the N-terminus at the cytoplasmic side of the membrane, able to interact with actin.
Catalog #C1384-04
During cardiac contractile dysfunction, the cardiotin distribution is affected in pathlogical cardiomyocytes i.e. chronic ischemic myocardium. R2G and SR-2, SR-3 and SR-4, monoclonal cardiotin antibodies can be used in immunohistochemistry for the detection of a disturbed mitochondrial activity in cardiomyocytes i.e. during chronic ischemia or chronic atrial fibrillation.
ApplicationsSuitable for use in Immunohistochemistry (human frozen sections) and Western Blotting (swine). Other applications not tested.
Optimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgM
Clone No4A20
HostMouse
SourceHuman
Concentration1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide. No stabilizing proteins added.
PurityPurified by Protein G affinity chromatography.
ImmunogenCardiotin
SpecificityReacts exclusively with the 300kD cardiotin protein complex in immunoblotting assays. The antibody stains cardiomyocytes and epithelial cells and tissues. Species crossreactivity: Human, porcine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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