Anti -Caspase 4, NT (Caspase-4, CASP 4, CASP4, CASP-4, Apoptotic Cysteine Protease
Mih1/TX, ICEREL-II, ICE(rel)-II, ICH 2, Ich-2, ICH2 Protease, Mih1/TX, Protease ICH-2,
Protease TX, TX)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
B IH |
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| Caspase-4, a member of the Caspase-1 subfamily of cysteine proteases, exists as an inactive pro-enzyme which undergoes proteolytic cleavage of its p30 precursor form, into smaller | | | p20 and p10 subunits. The cellular localisation of Caspase-4 on the Endoplasmic Reticulum (ER) membrane, has resulted in this protein becoming a focus of studies in which dysfunction or stress to the ER membrane is implicated, such as Alzheimer’s disease and Ischemia and confirms the involvement of Caspase-4 as an instigator of cellular apoptosis. | | | Catalog # | C2087-23T | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Western Blot: 1ug/ml; Detects a band of ~34kD in Ramos cell lysates (predicted precursor MW 31kD). | | Immunohistochemistry (Paraffin): 2ug/ml; Does not require protein digestion pre-treatment of paraffin embedded sections e.g. trypsin or pronase prior to staining. Does not require antigen retrieval using heat treatment prior to staining. | | Optimal dilutions to be determined by the researcher. | | IHC Positive Control | Spleen tissue | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified | | Immunogen | 16aa peptide from human Caspase-4 amino terminus. | | Specificity | Recognizes an epitope within the N-terminal region (NT) of human Caspase-4. Species Crossreactivity: mouse | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Apoptosis-related Cysteine Peptidase, EC=3.4.22.57 |
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Download Specifications for Anti -Caspase 4, NT (Caspase-4, CASP 4, CASP4, CASP-4, Apoptotic Cysteine Protease Mih1/TX, ICEREL-II, ICE(rel)-II, ICH 2, Ich-2, ICH2 Protease, Mih1/TX, Protease ICH-2, Protease TX, TX) |
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