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You are here:Home » Antibodies » Abs to Cathepsin » Anti -Cathepsin B (Procathepsin B)

Anti -Cathepsin B (Procathepsin B)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH
Cathepsin B is a cysteine protease commonly overexpressed in metastisizing cancer cells. An intracellular (lysosomal) enzyme in peptidase family C1 (papain family), Cathepsin B will hydrolyze proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
Catalog #C2097-11M
ApplicationsSuitable for use in Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionsImmunohistochemistry: 1:200. Paraffin sections after microwave treatment.
Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D231
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.01% thimerosal.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant human procathepsin B.
SpecificityRecognizes the epitope E212PGYSP217 of human cathepsin B. Recognizes mature human single or two chain cathepsin B and procathepsin B. Does not crossreact with mature cathepsins H, K, L, S, V, W or procathepsins L, S, W.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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