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You are here:Home » Antibodies » Abs to Ion Channel » Anti -Cav1.2 (Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-gated calcium channel subunit alpha Cav1.2, CACNA1C, Calcium channel L type, alpha-1 polypeptide isoform 1 cardiac muscle )

Anti -Cav1.2 (Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-gated
calcium channel subunit alpha Cav1.2, CACNA1C, Calcium channel L type, alpha-1 polypeptide
isoform 1 cardiac muscle )

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Where some ion channels permit the passage of ions based on charge, others conduct based on an ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature or mechanical forces. There are a few main classifications of gated ion channels. The first are voltage-gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor and cyclic nucleotide-gated channels. Ligand-gated ion channels open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. Specifially, Cav1.2 is a cardiac L-type calcium channel, and is important for excitation and contraction of the heart. It may be associated with a variant of Long QT syndrome called Timothy's syndrome and also with Brugada syndrome. Some references also suggest it is related to bipolar disease as well.
Catalog #C2097-85B4
ApplicationsSuitable for use in Western Blot, Immunoprecipitation, Immunofluorescence and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml. If results are poor, use lysate without boiling; heat at 37°C for 15 minutes.
Immunohistochemistry: 0.1-1ug/ml using peroxidase method
Immunohistochemistry: 1-10ug/ml using Immunofluorescence.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No10F687
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide, 50% glycerol.
PurityPurified by Protein G affinity chromatography.
ImmunogenFusion protein corresponding to aa1507-1733 (intracellular, carboxyl terminus) of rabbit Cav1.2 (Accession #P15381).
SpecificityRecognizes Cav1.2 at ~240kD. Species Crossreactivity: human, rat and mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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