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You are here:Home » Antibodies » Abs to G Proteins » Anti -CCR5 (Chemokine Receptor 5, CC-CCR-5)

Anti -CCR5 (Chemokine Receptor 5, CC-CCR-5)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IH IC
Receptors for the C-C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. The HIV receptor is composed of two molecules, the CD4 binding receptor and a co-receptor. The chemokine receptor CCR 5 is one of the co-receptors used by primary isolates of HIV-1. Extracellular domains of CCR 5 are important for HIV entry into the target cells.
Catalog #C2099-69
ApplicationsSuitable for use in Western Blot, ELISA, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionELISA: 1:50,000
Immunocytochemistry: 1:300
Immunohistochemistry (Paraffin): 1:300
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive Control  
Human peripheral blood cells or paraffin sections of spleen.  
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~2mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: YQVSSPIYDINYYTSEPCQKINVKQIAA (Human) corresponding to amino acids 3-30 of human CCR5.
Cellular LocalizationIntegral membrane protein.
SpecificityRecognizes human CCR5. Binds to CCR5 receptors on human peripheral blood leukocytes as determined by immunocytochemistry.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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