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You are here:Home » Antibodies » Abs to CD Markers » Anti -CD44 (HCAM, Homing Cell Adhesion Molecule, Pgp-1, Phagocytic Glycoprotein-1, Hermes Antigen, Lymphocyte Homing Receptor, ECM-III, HUTCH-1)

Anti -CD44 (HCAM, Homing Cell Adhesion Molecule, Pgp-1, Phagocytic Glycoprotein-1, Hermes
Antigen, Lymphocyte Homing Receptor, ECM-III, HUTCH-1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified IH FC
CD44 is the receptor for hyaluronan. The interaction between CD44 and hyaluronan may mediate binding of cells to basement membranes. Several CD44 isoforms or variants arise from alternative splicing of mRNA transcribed from a single gene located on chromosome 11. The alternatively spliced mRNA’s are translated into a family of protein isoforms which contain inserts in their cytoplasmic domains of varying lengths. Most cell types express the standard CD44, while the expression of the isoforms resulting from the alternative splicing is of limited distribution. CD44 isoforms resulting from alternative splicing have been detected in many human tumors; therefore, the identification of CD44 isoforms has utility in cancer studies.
Catalog #C2398-09C
Applications
Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
Flow Cytometry: 1:20
Immunohistochemistry (acetone fixed frozen sections or cell smears): 1ug/ml APAAP or PAP procedure or the three stage immunoperoxidase technique.
Immunohistochemistry (paraffin sections): 2ug/ml; after 2x microwave treatment for 5 minutes.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D27
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2-7.4.
PurityPurified 95% (SDS-PAGE).
ImmunogenRecombinant human CD44.
SpecificityRecognizes human CD44. Does not distinguish between CD44 splice variants (exons v3-v10).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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