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C2401-02K Mouse Anti-CD46 (CD46 Antigen, CD46 Molecule, AHUS2, Antigen Identified by Monoclonal TRA-2-10, Complement Membrane Cofactor Protein, Measles Virus Receptor, Membrane Cofactor Protein Precursor, MCP, MIC10, TLX, TRA2.10, Trophoblast Leukocyte Common Antigen)

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
P15529
Isotype
IgG1
Clone Number
MEM-258
Grade
Affinity Purified
Applications
FC IP WB
Crossreactivity
Bo Hu
Gene ID
4179
Shipping Temp
Blue Ice
Storage Temp
-20°C
CD46 Molecule Complement Regulatory Protein

CD46, also designated membrane cofactor protein, is a 45-70kD protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to down-regulate the activation of complement on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. The isoforms differ in the length. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)).

Applications
Suitable for use in Western Blot, Immunoprecipitation and Flow Cytometry. Other applications not tested.
Recommended Dilutions
Flow Cytometry: 1ug/ml Western Blot: non-reducing conditions Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
HPB-ALL human T cell line
Form
Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CD46. Species Crossreactivity: bovine
References
1. Okada N, et al. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2489-93.|2. Marie JC, et al. Nat Immunol. 2002 Jul; 3(7):659-66.|3. Fleischli C, et al. J Virol. 2005 Aug; 79(15):10013-22.|4. Weyand NJ, et al. Infect Immun. 2006 Apr; 74(4):2428-35.
USBio References
No references available
Conjugates
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