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You are here:Home » Antibodies » Abs to CD Markers » Anti -CD81 (TAPA-1, Target of anti-Proliferative Antibody-1)

Anti -CD81 (TAPA-1, Target of anti-Proliferative Antibody-1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH FC IF
CD81 has a very broad cellular distribution, being expressed on T and B lymphocytes, NK cells, thymocytes, eosinophils, fibroblasts, epithelial and endothelial cells (1). Neutrophils, erythrocytes and platelets are negative, while monocytes are variably positive (1). CD81 is a member of a family of tetraspans transmembrane proteins, including CD9, CD37, CD53, CD63, and CD82 (3). It associates with CD19, CD21, Leu 13, and integrins on cell membrane and is involved in signal transduction in B lymphocyte development and cell adhesion. CD81 also acts as a receptor for the envelope protein E2 of chronic hepatitis C virus (8). Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas.
Catalog #C2433-10
ApplicationsSuitable for use in Flow Cytometry, Immunofluorescence and Immunohistochemistry. For FunctionalStudies use C2433-10X. Other applications have not been tested.
Recommended DilutionImmunohistochemistry: Acetone fixed frozen sections
Optimal dilutions to be determined by the researcher.
Positive ControlDaudi, Raji, U266, HUT-78, HUT-102, Jurkat, HL-60, KG1a, A293, A431, MG63, human lymphocytes, tonsil and lymph node.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No0.N.165
HostMouse
SourceHuman
Concentration~0.2mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.1% sodium azide. Also available without BSA and azide. See C2433-10X.
PurityPurified by Protein G affinity chromatography.
ImmunogenB cell line derived from a Burkitt lymphoma. Cellular Localization: Cell membrane
SpecificityRecognizes human CD81/TAPA-1 at 24kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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