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You are here:Home » Antibodies » Abs to Neuroscience » Anti -Collapsin Response Mediator Protein 1 (CRMP1, Dihydropyrimidinase-like 1, DPYSL1, DRP1, ULIP3, CRAM)

Anti -Collapsin Response Mediator Protein 1 (CRMP1, Dihydropyrimidinase-like 1, DPYSL1,
DRP1, ULIP3, CRAM)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites B
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum,
hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydropyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin
(NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.
Catalog #C7517
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionImmunoblot Analysis: A 1:5001:2000 dilution of this lot detected CRMP1 in lung adenocarcinoma CL-1 and HeLa whole cell lysates.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgM
Clone No5H23
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid with 0.05% sodium azide before the addition of glycerol to 30%.
PurityAscites
ImmunogenHis6-tagged fusion protein corresponding to aa76-572 of human CRMP1.
SpecificityRecognizes CRMP1, Mr ~60-65kD. Additional non-specific bands of 50-55kD detected in long exposures. Species Crossreactivity: Human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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