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C7517 Mouse Anti-Collapsin Response Mediator Protein 1 (CRMP1, Dihydropyrimidinase-like 1, DPYSL1, DRP1, ULIP3, CRAM)

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
Q14194
Isotype
IgM,k
Clone Number
Y21
Grade
Ascites
Applications
WB
Crossreactivity
Hu
Accession #
NM_001313
Shipping Temp
Blue Ice
Storage Temp
-20°C

Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydropyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1:500-1:2000 dilution of this lot detected CRMP1 in lung adenocarcinoma CL-1 and HeLa whole cell lysates. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
His6-tagged fusion protein corresponding to aa76-572 of human CRMP1.
Form
Supplied as a liquid in 0.05% sodium azide before the addition of glycerol to 30%.
Purity
Ascites
Specificity
Recognizes human CRMP1, Mr ~60-65kD. Additional non-specific bands of 50-55kD detected in long exposures.
References
1. Shih, JY., et al. J Natl. Cancer Inst. 93: 1392-1400, 2001. 2. Steeg, P.S., J. Natl. Cancer Inst. 18: 1364-1365, 2001.
USBio References
No references available
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