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Specifications

Clone Host Grade Applications Polyclonal Goat Serum E

C4 consists of three polypeptide chains (alpha, molecular weight 95kD, beta, molecular weight 75kD and gamma, molecular weight 33kD) and is usually present in serum at 200-600mg/L. It is a protein of the classical complement pathway. When activated by C1s, a peptide C4a is released and the generated C4b binds C2 which is in turn cleaved by C1s to produce the classical pathway C3 convertase, namely C4b2a. C4b also has opsonin activity and binds to macrophages and neutrophils via their CR1 receptor.
Catalog #	C7850-15
Applications	Suitable for use in ELISA. Other applications not tested.
Recommended Dilutions	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone Type	Polyclonal
Isotype	IgG
Host	Goat
Source	Human
Concentration	Not Determined
Form	Supplied as a liquid in TBS, pH 7.5, 0.1% sodium azide
Purity	Serum
Immunogen	Purified human C4 protein
Specificity	Recognizes human complement component C4 (pooled normal human plasma and pooled 2X concentrated human serum) by immunoelectrophoresis
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.