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You are here:Home » Antibodies » Abs to Complement » Anti -Complement C4, Human

Anti -Complement C4, Human

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Specifications

Clone Host Grade Applications
Polyclonal Goat Serum E
C4 consists of three polypeptide chains (alpha, molecular weight 95kD, beta, molecular weight 75kD and gamma, molecular weight 33kD) and is usually present in serum at 200-600mg/L. It is a protein of the classical complement pathway. When activated by C1s, a peptide C4a is released and the generated C4b binds C2 which is in turn cleaved by C1s to produce the classical pathway C3 convertase, namely C4b2a. C4b also has opsonin activity and binds to macrophages and neutrophils via their CR1 receptor.
Catalog #C7850-15
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in TBS, pH 7.5, 0.1% sodium azide
PuritySerum
ImmunogenPurified human C4 protein
SpecificityRecognizes human complement component C4 (pooled normal human plasma and pooled 2X concentrated human serum) by immunoelectrophoresis
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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