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You are here:Home » Antibodies » Abs to Connexin, Junction Proteins » Anti -Connexin 43 (Cx43, Gap Junction Alpha 1 Protein, CxA-1)

Anti -Connexin 43 (Cx43, Gap Junction Alpha 1 Protein, CxA-1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy. Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of Connexin43 is known to be regulated by phosphorylation at Ser368 by protein kinase C. Phosphorylation of Ser368 by PKC induces a conformational change of Connexin43 that results in a decrease in gap junction permeability.
Catalog #C7857-01D
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceRat
ConcentrationNot determined
Form10 mM HEPES [pH7.5], 150 mM NaCl 100ug/ml BSA with 50% glycerol
PurityPurified by immunoaffinity chromatography.
ImmunogenPeptide corresponding to amino acid residues surrounding the C-terminus of rat Connexin43.
SpecificitySpecific for ~43k Connexin43 protein. Species Crossreactivity: Human, mouse, non-human primates, and rat based on 100% antigen sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesGap junction alpha-1 protein, Cx43, Connexin43, Connexin-43, Gap junction 43kD heart protein


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