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You are here:Home » Antibodies » Abs to Connexin, Junction Proteins » Anti -Connexin 43 (Cx43, Gap Junction alpha 1 Protein, CxA-1, Gap Junction 43kD Heart Protein, GJA1, GJAL)

Anti -Connexin 43 (Cx43, Gap Junction alpha 1 Protein, CxA-1, Gap Junction 43kD Heart
Protein, GJA1, GJAL)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH IC
Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy. Connexin43 (Cx43) forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of Cx43 is known to be regulated by phosphorylation at Ser368 by protein kinase C. Phosphorylation of Ser368 by PKC induces a conformational change of Cx43 that results in a decrease in gap junction permeability.
Catalog #C7857-01H
ApplicationsSuitable for use in Western Blot, Immunohistochemistry, and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 2ug/ml
Immunohistochemistry: 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.4, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenPeptide mapping at the C-terminus of human Connexin 43, identical to the related rat and mouse sequence.
SpecificityRecognizes human Connexin 43. Species Cross-Reactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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