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You are here:Home » Antibodies » Abs to Enzymes, Cyclooxygenase (COX) » Anti -COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)

Anti -COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IH
Cyclooxygenase (COX) is a membrane-bound enzyme, which has a molecular weight of 71kD. It is an enzyme that catalyzes the synthesis of cyclic endoperoxides from arachidonic acid to form prostaglandins (lipid-soluble, hormone-like regulatory molecules). Two isoforms of COX have been identified and are known as COX-1 and COX-2. COX-2 is dimeric and is the inducible (i.e., sites of inflammation) isoform of cyclooxygenase . It is normally localized to the endoplasmic reticulum and the nuclear envelope. COX-2 is upregulated in response to endotoxins, pro-inflammatory cytokins, growth factors, hormones, and tumor promoters and in carcinomas, including, sporadic colorectal, breast, pancreatic and cervical carcinomas. It is thought that COX-2 has a role in apoptosis, as well as in carcinogenesis. COX-2 is also constitutively expressed in the brain and kidney. COX-2 is normally undetectable in many tissues.
Catalog #C7904-83D
ApplicationsSuitable for use in Immunohistochemistry. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry: Frozen and formalin-fixed, paraffin-embedded tissue sections.
Optimal dilutions to be determined by the researcher.
Recommended Positive Control Colon carcinoma
Epitope Retrieval Required (Citrate Buffer, pH 6.0)
Enzyme Digestion Not Required
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No6A53
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
PurityPurified
ImmunogenSynthetic peptide corresponding to human COX-2. Expected Staining Pattern: Cytoplasm.
SpecificityRecognizes human COX-2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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