Anti -COX 2 (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
IH |
|
| Cyclooxygenase (COX) is a membrane-bound enzyme, which has a molecular weight of 71kD. It is an enzyme that catalyzes the synthesis of cyclic endoperoxides from arachidonic acid to form prostaglandins (lipid-soluble, hormone-like regulatory molecules). Two isoforms of COX have been identified and are known as COX-1 and COX-2. COX-2 is dimeric and is the inducible (i.e., sites of inflammation) isoform of cyclooxygenase . It is normally localized to the endoplasmic reticulum and the nuclear envelope. COX-2 is upregulated in response to endotoxins, pro-inflammatory cytokins, growth factors, hormones, and tumor promoters and in carcinomas, including, sporadic colorectal, breast, pancreatic and cervical carcinomas. It is thought that COX-2 has a role in apoptosis, as well as in carcinogenesis. COX-2 is also constitutively expressed in the brain and kidney. COX-2 is normally undetectable in many tissues. | | | Catalog # | C7904-83D | | Applications | Suitable for use in Immunohistochemistry. Other applications have not been tested. | | Recommended Dilutions | Immunohistochemistry: Frozen and formalin-fixed, paraffin-embedded tissue sections. | | Optimal dilutions to be determined by the researcher. | | Recommended Positive Control | Colon carcinoma | | Epitope Retrieval | Required (Citrate Buffer, pH 6.0) | | Enzyme Digestion | Not Required | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1,k | | Clone No | 6A53 | | Host | Mouse | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.1% sodium azide. | | Purity | Purified | | Immunogen | Synthetic peptide from human COX-2 Expected Staining Pattern: Cytoplasm. | | Specificity | Recognizes human COX-2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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