CRABP2 (Cellular retinoic acid binding protein type II; also RABP2) is a 14kD cytosolic member of the fatty acid binding protein family of molecules. It is expressed by a variety of cell types, including keratinocytes, corneal epithelium, fibroblasts and visceral smooth muscle. CRABP2 binds bioactive retinoic acid and transports it to the nucleus, where, in contrast to CRABP1, it facilitates its transfer to the retinoic acid receptor. Human CRABP2 is 138aa in length and contains one NLS (aa21-31) and a series of beta-strands forming a beta-barrel that accommodates retinoic acid in its interior (aa41-135).
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