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C8350-06B Rabbit Anti-CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Rat
Isotype
IgG
Grade
Affinity Purified
Applications
FC IHC N WB
Crossreactivity
Mo Rt
Shipping Temp
Blue Ice
Storage Temp
-20°C

CXCR4 (fusin) is a members in the seven-transmembrane domain G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library1. Its ligand is chemokine stroma-derived factor (SDF). CXCR4 has been shown to be the co-receptor for HIV-1 binding to CD4 through the viral envelope glycoprotein gp1202. In other cases, CXCR4 can function as the only receptor for the interaction of HIV-2 with CD4 and host cells3. A mouse monoclonal antibody (12G5) to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.

Applications
Suitable for use in Western Blot, Flow Cytometry, Immunohistochemistry and Neutralization. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000 Flow Cytometry: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
E.coli-expressed N-terminal rat CXCR4, aa2-38
Form
Supplied as a lyophilized powder, 0.09% sodium azide. Reconstitute with 200ul sterile ddH2O.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes rat CXCR4. Species Crossreactivity: mouse
References
1. Federsppiel, B. et al. (1993) Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated form human spleen. Genomics 16 (3): 707-12 2. Nagasawa, T. et al. (1998) A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV. Semin Immunol 10 (3): 179-85 3. Mcknight, A. et al. (1997) Inhibition of Human Immunodeficiency Virus Fusion by a Monoclonal Antibody to a Coreceptor (CXCR4) Is both Cell Type and Virus Strain Dependent. J. Virol., 71 (2): 1692-1696.
USBio References
No references available
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