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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184)

Anti -CXCR4 (Fusin, LESTR, HUMSTR, C-X-C Chemokine Receptor 4, CD184)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
CXCR4 (fusin) is a members in the seven-transmembrane domain G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library1. Its ligand is chemokine stroma-derived factor (SDF). CXCR4 has been shown to be the co-receptor for HIV-1 binding to CD4 through the viral envelope glycoprotein gp1202. In other cases, CXCR4 can function as the only receptor for the interaction of HIV-2 with CD4 and host cells3. A mouse monoclonal antibody (12G5) to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.
Catalog #C8350-06B
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:2000
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceRat
Concentration~1mg/ml
FormSupplied as a lyophilized powder in 0.1% sodium azide. Reconstitute to 1mg/ml by adding 200ul sterile dH2O.
PurityPurified by Protein A affinity chromatography.
ImmunogenE. coli-expressed rat CXCR4
SpecificityReacts with rat and mouse CXCR4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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