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You are here:Home » Antibodies » Abs to Cyclin » Anti -Cyclin D1 (G1/S-specific Cyclin-D1, B-cell Lymphoma 1 Protein, BCL-1, BCL-1 Oncogene, PRAD1 Oncogene, CCND1, BCL1, PRAD1)

Anti -Cyclin D1 (G1/S-specific Cyclin-D1, B-cell Lymphoma 1 Protein, BCL-1, BCL-1
Oncogene, PRAD1 Oncogene, CCND1, BCL1, PRAD1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP IH IC FC
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Catalog #C8454-01B2
ApplicationsSuitable for use in ELISA, Flow Cytometry, Immunocytochemistry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Immunocytochemistry: 1ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Immunohistochemistry (Frozen): 2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone NoCD1.1
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 15mM sodium azide, pH 7.4.
PurityPurified by Protein A affinity chromatography.
ImmunogenPurified cyclin D1
SpecificityRecognizes human CCND1. Species sequence homology: rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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