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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified B IH IC FC

Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40kD and 68kD and isoelectric pH between 4.9-7.8. The individual cytokeratin polypeptides are designated 1 to 20. Cytokeratin 1 has the highest molecular weight and the highest isoelectric pH, while cytokeratin 19 has the lowest molecular weight and a low isoelectric pH. The cytokeratins are divided into the type I and type II subgroups, the type II family members comprising the basic to neutral cytokeratins 1-8, while the type I group comprises the acidic cytokeratins 9-20. The cytokeratins are expressed in combinations which characterize the type of epithelium. Cytokeratin 19 is the smallest human cytokeratin (40kD) and is found in many simple and invariably in some non-keratinizing stratified squamous epithelia. All adenocarcinomas tested have been positive for cytokeratin 19.
Catalog #	C9097-28C
Applications	Western blot
	Immunohistochemistry on frozen tissue sections.
	Immunocytochemistry
	Flow cytometry
Clone Type	Monoclonal
Clone No	2Q1119
Host	Mouse
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in buffer with 0.1% sodium azide.
Purity	Purified IgG from culture supernatant.
Immunogen	Cytoskeletal preparation of T24 cell
Specificity	Reacts with glandular epithelial cells and most carcinomas. Does not react with hepatocytes and hepatocarcinoma. Recognizes human.
Important Note	This product is intended for research use only, not for use in human, therapeutic or diagnostic applications.