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You are here:Home » Antibodies » Antibodies-Notch Proteins » Anti -DNER (Delta and Notch-like Epidermal Growth Factor-related Receptor, Brain EGF Repeat Containing Transmembrane Protein, BET)

Anti -DNER (Delta and Notch-like Epidermal Growth Factor-related Receptor, Brain EGF
Repeat Containing Transmembrane Protein, BET)


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Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IC
DNER, also known as brain EGF repeat containing transmembrane protein (BET), is a neuron-specific type I transmembrane notch ligand that is expressed on membranes of dendrites and cell bodies but not axons. It contains ten extracellular EGF-like domains and one follistatin-like domain (between the 9th and 10th EGF-like domains). DNER mediates neuron-glia interactions and is required for the functional and morphological maturation of the cerebellum. The extracellular domains of human and mouse DNER share 89% amino acid sequence homology.
Catalog #D4016-85
ApplicationsSuitable for use in ELISA, Immunocytochemistry and Western Blot. Other applications not tested.
Recommended DilutionImmunocytochemistry: 5-15ug/ml (used with immersion fixed A172 human glioblastoma cells)
Western Blot: 0.2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
Concentration~0.2mg/ml (upon reconstitution)
FormSupplied as a powder lyophilized from a solution containing PBS with 5% trehalose. Reconstitute to 0.2mg/ml with 500ul sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenNS0-derived rhDNER (aa 29-637, UniProt Accession # Q8NFT8)
SpecificityRecognizes human DNER. In direct ELISAs and Western Blots, this antibody shows ~30% crossreactivity with rmDNER.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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