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D8066-83C Rabbit Anti-DISC1 (Disrupted in Schizophrenia 1, RP4-730B13.1, KIAA0457, SCZD9)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q9NRI5
Isotype
IgG
Grade
Affinity Purified
Applications
IHC WB
Crossreactivity
Hu Mo
Shipping Temp
Blue Ice
Storage Temp
-20°C

The DISC1 protein is widely expressed in normal tissues. It is involved in neurite outgrowth and cortical development through its interaction with a variety of proteins including lissencephaly-1 (LIS1), NudeE-like (NUDEL) and phosphodiesterase 4B. In certain cases of schizophrenia the DISC1 gene has been found to be disrupted by a t(1;11) (q42.1;q14.3) translocation, and studies suggest that DISC1 could be a candidate susceptibility gene for this condition.

Applications
Suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry. Other applications not tested.
Recommended Dilutions
Western Blot: 1-2ug/ml detects bands of approximately 95-100kD in SK-N-SH cell lysate. Immunocytochemistry: 5ug/ml Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
An 18 amino acid peptide located near the center of human DISC1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
Purity
Purified by affinity chromatography.
Specificity
Recognizes disrupted in schizophrenia 1 (DISC1), 93kD protein located in the nucleus, cytoplasm and mitochondria. Species Crossreactivity: human and mouse
References
1. Taya, S. et al. (2007) DISC1 regulates the transport of the NUDEL/LIS1/14-3-3eta complex through kinesin-1. J Neurosci. 27:15 - 26
USBio References
No references available
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