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You are here:Home » Antibodies » Abs to Translation Initiation Factors » Anti -Eukaryotic Translation Initiation Factor 4G (eIF4G)

Anti -Eukaryotic Translation Initiation Factor 4G (eIF4G)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IH IC FC IF
The initiation of translation is an important biological event, and a variety of factors contribute to this process. The eIF4 family of translation initiation factors bind to the 5' m7GTP mRNA cap and function to unwind the secondary structure of mRNA (1, 2). The amino-terminal portion of eIF4G physically associates with eIF4E and stimulates the binding of eIF4E to the mRNA cap structure (3). eIF4G also interacts with eIF3 and eIF4A (4), serving as an adaptor molecule in the eIF4 complex. Moreover, eIF4G also plays a role in internal ribosomal entry site (IRES)-mediated initiation of translation (5,6).
Catalog #E8949-54
ApplicationsSuitable for use in Immunofluorescence, Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No7H21
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol and less than 0.02% sodium azide.
PuritySupernatant
ImmunogenSynthetic peptide (KLH-coupled) derived from the sequence around Gly188 of human eIF4G.
SpecificityDetects endogenous levels of total human eIF4G protein. Species Crossreactivity: Monkey, mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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