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F6024-02 Forskolin (7b-Acetoxy-8,13-epoxy-1a,6b,9a-trihydroxy- labd-14-ene-11-one, Coleonol, Colforsin) CAS: 66575-29-9

Specifications
References
CAS Number
66575-29-9
Grade
Highly Purified
Molecular Formula
C22H34O7
Molecular Weight
410.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Forskolin is a naturally occurring diterpene from the Indian plant, Coleus forskohlii, that works as an activator of adenylate cyclase resulting in an increase in the intracellular concentration of cAMP.

Solubility
Soluble in DMSO (5mg/ml) or ethanol (6mg/ml).
Melting Point
226-229ºC
Elemental Analysis
Calculated: C=64.37%, H=8.35%
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Purity
~99%
Form
Supplied as a white crystalline powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Laurenza, A., et al. "Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?" Trends Pharm. Sci. 10:442-447 (1989). 2. Barber, R. and Goka, T.J. "Adenylate cyclase activity as a function of forskolin concentration." J. Cyclic Nucleotide Protein Phosphor. Res. 10:23-29 (1985). 3. Abe, A. and Karaki, H.J. "Effect of forskolin on cytosolic Ca++ level and contraction in vascular smooth muscle." J. Pharmacol. Exp. Ther. 249:895-900 (1989). 4. Joost, H.G. and Steinfelder, H.J. "Forskolin inhibits insulin-stimulated glucose transport in rat adipose cells by a direct interaction with the glucose transporter." Mol. Pharmacol. 31:279 (1987). 5. Martin, G.E., et al. "Forskolin specifically inhibits the bacterial galactose-H+ transport protein, GalP." J. Biol. Chem. 269:24870-24877 (1994). 6. Siddhanti, S.R., et al. "Forskolin inhibits protein kinase C-induced mitogen activated protein kinase activity in MC3T3-E1 osteoblasts." Endocrinology. 136:4834-4841 (1995).
USBio References
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