GLI was first identified as a gene amplified in a malignant glioma (1) and can transform primary cells in cooperation with adenovirus E1A (2). GLI belongs to the Kruppel family of zinc finger proteins and there are three GLI proteins in mammals: GLI1, GLI2 and GLI3 (3). GLI proteins, similar to their Drosophila homolog Ci (Cubitus interruptus), function as transcription factors activated by the Hedgehog signaling pathway which plays an important role in animal development and is aberrantly activated in many types of cancers (4,5). GLI1 itself is a transcriptional target of the Hedgehog signaling pathway (6-8) and is used as a marker of Hedgehog signaling activation in cancer research (9,10).
Product | Size | List | Your Price | Qty | Ext Price | ||||
---|---|---|---|---|---|---|---|---|---|
Subtotal: | Subtotal: | ||||||||
Subtotal: | Subtotal: | ||||||||
Total Coupon Savings: | Total Coupon Savings: | () | |||||||
Your cart is currently empty. | |||||||||
- Coupon Code |