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Abs to Glucose Transporters
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Anti -GLUT2 (Solute Carrier Family 2, Facilitated Glucose Transporter Member 2, Glucose Transporter Type 2, Liver, GLUT-2, SLC2A2)
Anti -GLUT2 (Solute Carrier Family 2, Facilitated Glucose Transporter Member 2, Glucose
Transporter Type 2, Liver, GLUT-2, SLC2A2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B FC |
|
| Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters. Molecular cloning of these glucose transporters has identified a family of closely related genes that encodes at least 7 proteins (Glut-1- Glut-14, Mol. Wt. 40-80kD) and Sodium glucose co-transporter- 1 (SGLT-1, 662aa; ~75kD). Individual member of this family have identical predicted secondary structures with 12 transmembrane domains. Both N and c-termini are predicted to be cytoplasmic. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue-specific targeting. | | | Catalog # | G3900-15B | | Human Glut-2 (GTR2, 524aa, chromosome 3q26.1-q26.3, ~60kD) belongs to the family of solute carrier family 2, member 2 or Slc2a2 or facilitative glucose transporter. Glut-2 likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. It is a multi-pass membrane protein. Primarily expressed in liver, insulin-producing beta cell, small intestine and kidney. Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS, a rare, autosomal recessive mode and characterized by hepatorenal glycogen accumulation, and impaired utilization of glucose and galactose. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1). | | Applications | Suitable for use in Western Blot and Flow Cytometry. Other applications not tested. | | Recommended Dilution | Western Blot: 1-5ug/ml (chemiluminescence) | | Flow Cytometry: ~10ug/ml (10e5 cells) Perform the antibody binding in small volume of ~200ul. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 11C101 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a lyophilized powder from PBS, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant corresponding to human glut-2, Extracellular domain. | | Specificity | Recognizes human Glut-2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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