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You are here:Home » Antibodies » Abs to Glucose Transporters » Anti -GLUT2 (Solute Carrier Family 2, Facilitated Glucose Transporter Member 2, Glucose Transporter Type 2, Liver, GLUT-2, SLC2A2)

Anti -GLUT2 (Solute Carrier Family 2, Facilitated Glucose Transporter Member 2, Glucose
Transporter Type 2, Liver, GLUT-2, SLC2A2)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B FC
Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters. Molecular cloning of these glucose transporters has identified a family of closely related genes that encodes at least 7 proteins (Glut-1- Glut-14, Mol. Wt. 40-80kD) and Sodium glucose co-transporter- 1 (SGLT-1, 662aa; ~75kD). Individual member of this family have identical predicted secondary structures with 12 transmembrane domains. Both N and c-termini are predicted to be cytoplasmic. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue-specific targeting.
Catalog #G3900-15B
Human Glut-2 (GTR2, 524aa, chromosome 3q26.1-q26.3, ~60kD) belongs to the family of solute carrier family 2, member 2 or Slc2a2 or facilitative glucose transporter. Glut-2 likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. It is a multi-pass membrane protein. Primarily expressed in liver, insulin-producing beta cell, small intestine and kidney. Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS, a rare, autosomal recessive mode and characterized by hepatorenal glycogen accumulation, and impaired utilization of glucose and galactose. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1).
ApplicationsSuitable for use in Western Blot and Flow Cytometry. Other applications not tested.
Recommended DilutionWestern Blot: 1-5ug/ml (chemiluminescence)
Flow Cytometry: ~10ug/ml (10e5 cells) Perform the antibody binding in small volume of ~200ul.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No11C101
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to human glut-2, Extracellular domain.
SpecificityRecognizes human Glut-2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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