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G4005-55 Guinea pig Anti-Glutamate Transporter, Glial (SLC1A2, EAAT2, GLT1, Excitatory Amino Acid Transporter 2, Solute Carrier Family 1 Member 2) (Not for Export EU)

Specifications
References
Clone Type
Polyclonal
Host
Guinea pig
Source
Rat
Swiss Prot
P43004
Isotype
IgG
Grade
Serum
Applications
IF IHC WB
Crossreactivity
Hu Mo Rt
Accession #
NM_004171.3
Shipping Temp
Blue Ice
Storage Temp
-20°C

Glutamate transporters (GluT) function to remove L-glutamate (Glu), the primary excitatory neurotransmitter in the mammalian central nervous system (CNS), from the synaptic cleft. By clearing the synapse in this manner Glu can be recycled for later use, the proper diffusion gradient can be maintained and excitotoxicity can be prevented. There have been reports of many different members of a GluT multigene family; GLT1, GLAST, EAAC1 and EAAT2. mRNA has been identified in brain for each of these proteins.

EAAT2 transports L-glutamate and also L- and D-aspartate. It is essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Applications
Suitable for use in Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested.
Recommended Dilutions
Immunohistochemistry (Paraffin): 1:1000-1:4000 Immunohistochemistry: 1:5000-10,000 Western Blot: 1:500 detected GLT-1 on 10ug of mouse brain lysates Optimal dilution to be determined by researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to the C-terminal of rat GLT-1.
Form
Supplied as a liquid, 0.05% sodium azide
Purity
Serum
Specificity
Recognizes rat Glial Glutamate Transporter GLT1 (EAAT2). |Species Crossreactivity: human and mouse
References
1. Nature (1992) 360:464–467. 2. Annals of Neurology (1995) 38:73–84. 3. Neuron (1994) 13:713–725.
USBio References
No references available
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