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You are here:Home » Antibodies » Abs to Transport Proteins » Anti -Glutamate Transporter, Glial (GLAST, EAAT1, GLT-1)

Anti -Glutamate Transporter, Glial (GLAST, EAAT1, GLT-1)

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Specifications

Clone Host Grade Applications
Polyclonal Guinea pig Serum B IH IF
Glutamate transporters (GluT) function to remove L-glutamate (Glu), the primary excitatory neurotransmitter in the mammalian central nervous system (CNS), from the synaptic cleft. By clearing the synapse in this manner Glu can be recycled for later use, the proper diffusion gradient can be maintained and excitotoxicity can be prevented. There have been reports of many different members of a GluT multigene family; GLT1, GLAST, EAAC1 and EAAT2. mRNA has been identified in brain for each of these proteins.
Catalog #G4005-55
EAAT2 transports L-glutamate and also L- and D-aspartate. It is essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
ApplicationsSuitable for use in Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Paraffin): 1:1000 using heat-induced epitope retrieval (HIER).
Western Blot: 1:500 detected GLT-1 on 10ug of mouse brain lysates
Optimal dilution to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGuinea pig
SourceRat
ConcentrationNot Determined
FormSupplied as a liquid, 0.05% sodium azide
PuritySerum
ImmunogenSynthetic peptide corresponding to the C-terminal of rat GLT-1.
SpecificityRecognizes rat Glial Glutamate Transporter GLT-1 (EAAT2).
Species CrossreactivityHuman and mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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