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You are here:Home » Antibodies » Abs to Glucose Transporters » Anti -SLC17A7 (Vesicular Glutamate Transporter 1, VGluT1, Brain-specific Na(+)-dependent Inorganic Phosphate Cotransporter, Solute Carrier Family 17 Member 7, BNPI, VGLUT1)

Anti -SLC17A7 (Vesicular Glutamate Transporter 1, VGluT1, Brain-specific Na(+)-dependent
Inorganic Phosphate Cotransporter, Solute Carrier Family 17 Member 7, BNPI, VGLUT1)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified IH
Glutamate is the main excitatory neurotransmitter in the brain. To date five glutamate Transporters have been cloned: GLAST (EAAT1), GLT1 (EAAT2), EAAC1 (EAAT3), EAAT4, and EAAT5. These transporters are believed to be critical in reducing potentially toxic extracellular concentration of glutamate by rapid uptake into nerve terminals and glial cells. Most recently, vesicular type transporters for glutamate, termed VGLUTs (VGLUT1/BNPI, VGLUT2/DNPI, and EAT-4), have been cloned and characterized that are related to phosphate transporters. Although neurons exhibit Na-dependent Pi transport, the biological role of Pi uptake is not clear. Proximal tubules in the kidney reabsorb Pi in the glomeruli by the action of a group of phosphate transporters (Type 1-NaPi related, type 2-NaPi-2 related, and type 3-viral receptor-related. These receptors show weak (~20% identity) between various subtypes. A distinct type of brain specific Na+-dependent phosphate (Pi) transporter (BNPI), originally characterized as a plasma membrane transporter has been localized in a subset of glutamatergic neurons (amygdla,cereberal cortex, and hippocmaplus) and identified as VGLUT1 (rat and human 560 aa; ~60kD, ~30% homology with type-1 Pi-transporters & ~75-80% homology with VGLUT2). Interestingly, a sequence induced by subtoxic levels of NMDA in cerebelar granules also belongs to this family of transporters. BNPI/VGLUT1 is expression is restricted to the brain, where it is predominantly located in synaptic vesicles. VGLUT1 shows strong sequence homology (~48%) to EAT-4, a C. elegans protein that appears to have specific presynaptioc role in glutamtergic transmission.
Catalog #G4005-61H
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to HDQLAGSDDSEMED from the internal region of human VGluT1.
SpecificityRecognizes human SLC17A7.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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