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You are here:Home » Antibodies » Abs to Biochemicals » Anti -Glutathione (NEM)

Anti -Glutathione (NEM)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E IC FC
Glutathione is a tripeptide (gama-glutamylcysteinylglycine) molecule found in most mammmalian cells. It functions in basic metabolic processes such as serving as a sulfydryl buffer to maintain redox within the cell, participating in the transport of amino acids and detoxifying hydrogen and organic peroxides. Glutathione depletion can inhibit Th-1 associated cytokine production and favors a Th-2 associated immune response (3). Glutathione deficiency has also been linked to decreased patient survival in HIV-infected individuals. Overexpression of apoptotic protein Bcl-2 causes relocalization of glutathione from the cytoplasm into the nucleus where glutathione is thought to alter the redox and block caspase activity.
Catalog #G8123-01
ApplicationsSuitable for use in Flow Cytometry, ELISA
and Immunocytochemistry. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No4E91
HostMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1mM PMSF.
PurityPurified
ImmunogenThiol-modified glutathione, conjugated to KLH.
SpecificityRecognizes glutathione conjugated to NEM.
Species CrossreactivityMammals
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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