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You are here:Home » Antibodies » Abs to G Protein Receptors » Anti -G-Protein Coupled Receptor 119 (GPCR119, GPR119)

Anti -G-Protein Coupled Receptor 119 (GPCR119, GPR119)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH IC IF
GPR119 is an Orphan-U GPCR with an unknown ligand.
The G-protein-coupled receptor 119 is important in type II diabetes. It is expressed primarily in the pancreas and gastrointestinal tract. When GPR119 is activated in gut cells, it leads to insulin secretion from pancreatic beta cells. This insulin secretion is glucose-dependent and leads to the release of GLP1, GIP, and PYY, which are known to help regulate the diabetic response to dietary effects. GPR119 also is important in gut inflammation pathways.
Catalog #G8601-23
ApplicationsSuitable for use in Immunohistochemistry, Immunocytochemistry and Immunofluorescence. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:100. Antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Immunocytochemistry: 1:50
Immunofluorescence: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 30% glycerol.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide made to an internal region of the human GPR119 protein (within residues 150-250) (Q8TDV5).
Cellular LocalizationCell membrane; Multi-pass membrane protein. Species sequence homology: rat (88%)
SpecificityRecognizes human GPCR119. Species Crossreactivity:
mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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