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Anti -G-Protein Coupled Receptor 119 (GPCR119, GPR119)
Anti -G-Protein Coupled Receptor 119 (GPCR119, GPR119)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH IC IF |
|
| GPR119 is an Orphan-U GPCR with an unknown ligand. | | | The G-protein-coupled receptor 119 is important in type II diabetes. It is expressed primarily in the pancreas and gastrointestinal tract. When GPR119 is activated in gut cells, it leads to insulin secretion from pancreatic beta cells. This insulin secretion is glucose-dependent and leads to the release of GLP1, GIP, and PYY, which are known to help regulate the diabetic response to dietary effects. GPR119 also is important in gut inflammation pathways. | | | Catalog # | G8601-23 | | Applications | Suitable for use in Immunohistochemistry, Immunocytochemistry and Immunofluorescence. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 1:100. Antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. | | Immunocytochemistry: 1:50 | | Immunofluorescence: 1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 30% glycerol. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic peptide made to an internal region of the human GPR119 protein (within residues 150-250) (Q8TDV5). | | Cellular Localization | Cell membrane; Multi-pass membrane protein. Species sequence homology: rat (88%) | | Specificity | Recognizes human GPCR119. Species Crossreactivity: | | mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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