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You are here:Home » Antibodies » Abs to Ion Channel » Anti -HCN1 pore (Hyperpolarization-activated Cyclic Nucleotide-gated channel Pore)

Anti -HCN1 pore (Hyperpolarization-activated Cyclic Nucleotide-gated channel Pore)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
HCN channels pass both Na+ and K+ with relative permeability ratio of ~0.15 to 0.25. The primary sequence of HCN pore region is clearly related to that of highly selective K+ channels. In contrast to nonselective CNG or Na+-channels, both K+ and HCN channels contain a GYG motif in the pore. By affecting the spatial coordination of the GYG sequence in the tetrameric channel complex, other channel domains could control the structural rigidity of the pore and thereby determine whether only K+ or also other monovalent are allowed to permeate.
Catalog #H1827-31D
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1-10ug/ml using ECL.
ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well.
Optimal dilutions to be determined by the researcher.
Control PeptideH1827-31F: HCN1 pore, Human (Hyperpolarization-activated Cyclic Nucleotide-gated channel Pore)
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa346-368 (23aa) near the pore region of human HCN1, conjugated to KLH
SpecificityRecognizes human HCN1 pore. The pore region of HCN1 is very conserved among various HCNs. Species Sequence Homology
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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