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Anti -Indoleamine 2,3-dioxygenase (Indoleamine-pyrrole 2,3-dioxygenase, IDO, INDO, Indoleamine 2,3-dioxygenase 1, IDO1, IDO-1)
Anti -Indoleamine 2,3-dioxygenase (Indoleamine-pyrrole 2,3-dioxygenase, IDO, INDO,
Indoleamine 2,3-dioxygenase 1, IDO1, IDO-1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
B IH |
|
| Indoleamine-pyrrole 2,3-dioxygenase (IDO) is an enzyme responsible for the catabolism of tryptophan to N-formlkynurenine and kynurenine. With the exception of tryptophan oxidase in hepatocytes, IDO is the only enzyme that degrades the amino acid tryptophan to kynurenine. Chlamydial pathogens require tryptophan for growth. IDO can lower available tryptophan in target cells leading to conversion of the pathogen to persistant forms, with significance in the progression to chronic infection with its associated pathological effects. | | | Catalog # | I7545-06B | | Applications | Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested. | | Recommended Dilution | Immunohistochemistry: frozen sections | | Western Blot: Recognizes a 45kD band in IFN-gamma treated cell lines. Recognizes a slighty lower MW band in mouse IDO compared to its human counterpart. | | Optimal dilutions to be determined by the researcher. | | Recommended Secondary Antibodies | I1904-04D: IgG, H&L (AP) Pab Gt xMo | | I1904-06F: IgG, H&L (FITC) Pab Gt xMo | | I1904-06C: IgG, H&L (HRP) Pab Gt xMo | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Clone Type | Monoclonal | | Isotype | IgG3 | | Clone No | 10D255 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.1% sodium azide. | | Purity | Purified | | Immunogen | Peptide corresponding to aa78-184 of human IDO fused to GST. | | Specificity | Recognizes human Indoleamine-pyrrole 2,3 - dioxygenase (IDO). Species crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | EC=1.13.11.52, CD107B |
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