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You are here:Home » Antibodies » Abs to Integrin » Anti -Integrin, alpha 1 (ITGA1, CD49a, CD49a Antigen, Laminin and Collagen Receptor, Very Late Activation Protein 1, VLA1, VLA-1)

Anti -Integrin, alpha 1 (ITGA1, CD49a, CD49a Antigen, Laminin and Collagen Receptor, Very
Late Activation Protein 1, VLA1, VLA-1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Integrin a1 is a 190-210kD member of the integrin alpha chain family of molecules. It is found on smooth muscle cells, osteoblasts, adipocytes and intestinal epithelium. Integrin a1 forms a noncovalent heterodimer with Integrin b1, and serves as a divalent-cation dependent receptor for collagen types I, IV, VI, XIII and XVI. It also binds the diarrhea-associated NSP4 enterotoxin of rotavirus. Mature human Integrin a1 is a 1151aa type I transmembrane glycoprotein that contains a 1113aa extracellular domain (ECD) and a 15aa cytoplasmic tail. The ECD contains one vWFA/I-domain aa147-360 that binds collagen, plus multiple divalent cation binding sites. Potential splice variants exist that show a two and four aa substitution for aa765-1179. Over aa29-1141 (the ECD), human Integrin a1 shares 88aa identity with mouse Integrin a1.
Catalog #I7661-30L
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11n86
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa29-1141 from human Integrin a1/CD49a expressed in CHO cells (P56199).
SpecificityRecognizes human Integrin a1. No cross-reactivity with rhIntegrin a2, 3, 4, 5, 6, 8, 9, 10, 11, L, M, V, X, a6x1/b4, aD/b2, a7x2/b1, aE/b7, or a2b/b3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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