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I7661-30L Mouse Anti-Integrin, alpha 1 (ITGA1, CD49a, CD49a Antigen, Laminin and Collagen Receptor, Very Late Activation Protein 1, VLA1, VLA-1)

Specifications
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
P56199
Isotype
IgG1
Clone Number
11n86
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu
Gene ID
3672
Shipping Temp
Blue Ice
Storage Temp
-20°C

Integrin a1 is a 190-210kD member of the integrin alpha chain family of molecules. It is found on smooth muscle cells, osteoblasts, adipocytes and intestinal epithelium. Integrin a1 forms a noncovalent heterodimer with Integrin b1, and serves as a divalent-cation dependent receptor for collagen types I, IV, VI, XIII and XVI. It also binds the diarrhea-associated NSP4 enterotoxin of rotavirus. Mature human Integrin a1 is a 1151aa type I transmembrane glycoprotein that contains a 1113aa extracellular domain (ECD) and a 15aa cytoplasmic tail. The ECD contains one vWFA/I-domain aa147-360 that binds collagen, plus multiple divalent cation binding sites. Potential splice variants exist that show a two and four aa substitution for aa765-1179. Over aa29-1141 (the ECD), human Integrin a1 shares 88aa identity with mouse Integrin a1.

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 2ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Recombinant corresponding to aa29-1141 from human Integrin a1/CD49a expressed in CHO cells (P56199).
Form
Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
Purity
Purified by Protein A/G affinity chromatography.
Specificity
Recognizes human Integrin a1. No cross-reactivity with rhIntegrin a2, 3, 4, 5, 6, 8, 9, 10, 11, L, M, V, X, a6x1/b4, aD/b2, a7x2/b1, aE/b7, or a2b/b3.
Conjugates
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