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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -Interleukin 3 Receptor alpha (IL-3RA, IL-3R alpha, IL-3R, IL3RAX, IL3RX, IL3RAY, IL3RY, CD123, MGC34174)

Anti -Interleukin 3 Receptor alpha (IL-3RA, IL-3R alpha, IL-3R, IL3RAX, IL3RX, IL3RAY,
IL3RY, CD123, MGC34174)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH FC
IL3RA (CD123) is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either common beta chain (CDw131) or the IL3RB chain to form high affinity heterodimeric IL3 receptors. CDw131 can complex with the Alpha subunits of the mouse IL3R, IL5R and GMCSFR to form high affinity receptors, while the IL3RB subunit is specific for IL3 but binds with low affinity. IL3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. It is present in Hematopoietic progenitors, basophils, mast cells and megakaryocytes.
Catalog #I7663-47A
ApplicationsSuitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: Frozen sections
Western Blot: Detects a band at ~70kD
Flow Cytometry: Use 1ug to label 1x10e6 cells in 100ul.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No8L446
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenIL3R transfected COS cells. Cellular Localization: Type I membrane protein.
SpecificityRecognizes human IL3RA at ~70kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesInterleukin 3 Receptor alpha chain


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