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You are here:Home » Antibodies » Abs to Interleukin » Anti -Interleukin 6 Receptor (CD126, IL-6R)

Anti -Interleukin 6 Receptor (CD126, IL-6R)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified IC FC
IL-6 R, also known as CD126, is a transmembrane protein that associates with the signal-transducing subunit gp130 to form a high-affinity receptor complex for IL-6. It is expressed on T cells, activated B cells, and peripheral monocytes. A soluble form of IL-6 R can be released by proteolytic cleavage.
Catalog #I8428-39M
ApplicationsSuitable for use in Flow Cytometry and Immunocytochemistry. Other applications not tested.
Recommended DilutionsFlow Cytometry: 2.5ug/10e6 cells using mouse CD3+ splenocytes
Immunocytochemistry: 8-25ug/ml using immersion fixed mouse splenocytes
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypeMonoclonal
IsotypeIgG2a
Clone No8H130
HostRat
SourceMouse
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 1ml sterile PBS.
PurityPurified by Protein G affinity chromatography
ImmunogenRecombinant protein corresponding to aa20-357 from mouse IL-6R expressed in NSO cells (P22272).
SpecificityRecognizes mouse IL-6R. Does not crossreact with rhIL-6R.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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