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Anti -Kallmann Syndrome Protein (KAL1, ADMLX, HHA, KALIG-1, KALIG1, KMS)
Anti -Kallmann Syndrome Protein (KAL1, ADMLX, HHA, KALIG-1, KALIG1, KMS)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
|
E IH |
|
| Defects in the KAL1 gene are the cause of Kallmann syndrome type 1 (KAL1) [MIM:308700]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous. | | | KAL1 has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex. It is a chemoattractant for fetal olfactory epithelial cells. The predicted KAL1 protein sequence is similar to proteins known to function in neural cell adhesion and axonal migration. | | | Catalog # | K0005-85A | | Applications | Suitable for use in ELISA and Immunohistochemistry. Other applications have not been tested. | | Recommended Dilutions | | | ELISA: 1:1000 | | Immunohistochemistry (FFPE): 5ug/ml; Heat induced antigen retrieval in sodium citrate buffer, pH 6.0, is recommended. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide from human KAL1 | | Specificity | Recognizes human KAL1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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