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You are here:Home » Antibodies » Antibodies-Disease Markers » Anti -Kallmann Syndrome Protein (KAL1, ADMLX, HHA, KALIG-1, KALIG1, KMS)

Anti -Kallmann Syndrome Protein (KAL1, ADMLX, HHA, KALIG-1, KALIG1, KMS)


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Clone Host Grade Applications
Polyclonal Rabbit E IH
Defects in the KAL1 gene are the cause of Kallmann syndrome type 1 (KAL1) [MIM:308700]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
KAL1 has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex. It is a chemoattractant for fetal olfactory epithelial cells. The predicted KAL1 protein sequence is similar to proteins known to function in neural cell adhesion and axonal migration.
Catalog #K0005-85A
ApplicationsSuitable for use in ELISA and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
ELISA: 1:1000
Immunohistochemistry (FFPE): 5ug/ml; Heat induced antigen retrieval in sodium citrate buffer, pH 6.0, is recommended.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide from human KAL1
SpecificityRecognizes human KAL1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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