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Specifications

Clone Host Grade Applications Monoclonal Mouse Ascites E B RIA

Keratan sulfate (KS), also called keratosulfate, is any of several sulfated glycosaminoglycans (structural carbohydrates) that have been found especially in the cornea, cartilage, and bone. It is also synthesized in the central nervous system where it participates both in development[1] and in the glial scar formation following an injury. Keratan sulfates are large, highly hydrated molecules which in joints can act as a cushion to absorb mechanical shock.
Catalog #	K0197-01
Applications	Suitable for use in Western Blot, ELISA and RIA. May be used in a competitive inhibition assay to measure keratan sulfate levels. Other applications not tested.
Recommended Dilutions	Western Blot: 1:1000-1:4000
	ELISA: 1:5000-1:20,000
	RIA:1:30,000-1:500,000
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone Type	Monoclonal
Isotype	IgG2b
Clone No	2Q544
Host	Mouse
Source	Human
Concentration	Not Determined
Form	Supplied as a liquid. No preservative added.
Purity	Ascites
Immunogen	Human articular cartilage proteoglycan digested with chondroitinase ABC
Specificity	Recognizes 2-3 disaccharide units on both skeletal (type II) and corneal (type I) keratan sulfate chains either in isolated or proteoglycan-bound form. The epitope is resistant to proteolytic or alkaline cleavages and is partially sensitive to keratanase or other endo-b-galactosidase treatment. Species Crossreactivity: human, bovine, sheep, porcine, canine and mouse (adult). No crossreactivity with chicken limb bud proteoglycans, dermatan sulfate proteoglycans of cartilage and proteoglycans of rat chondrosarcomas
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.