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K1781-01A Mouse Anti-Kinesin 2 (Kinesin-2, KNS2, HK2, KIF2, KIF2A, Kinesin Heavy Chain Member 2, Kinesin-like Protein KIF2A, Kinesin Heavy Chain Member 2A)

Specifications
Clone Type
Monoclonal
Host
Mouse
Source
Human
Isotype
IgG1,k
Clone Number
2D4
Grade
Purified
Applications
E IHC WB
Crossreactivity
Hu
Accession #
AAH31828
Shipping Temp
Blue Ice
Storage Temp
-20°C

Kinesin heavy chain member 2 is a kinesin-like motor protein. The kinesin-related proteins are involved in functions related to movements of organelles, microtubules, or chromosomes along microtubules. These functions include axonal transport, microtubule sliding during nuclear fusion or division, and chromosome disjunction during meiosis and early mitosis. The kinesins are tetramers composed of 2 heavy and 2 light chains. The N-terminal heavy chain sequences show similarity in all the kinesin-related proteins. The N-terminal part forms the motor domain, with the microtubule-binding region allowing the protein to slide along the microtubule. It also possesses an ATP-binding site allowing an ATPase activity that provides the energy required for the movement. Kinesin-like motor proteins are found in several vertebrate cell types but is strongly expressed in neuronal cells. In dividing cells it is required for bipolar spindle formation and chromosome segregation. In neuronal cells it is involved in neurite outgrowth.

Applications
Suitable for use in ELISA, Immunohistochemistry (paraffin), and Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KIF2 (AAH31828, 1-680aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Form
Supplied as a liquid in PBS, pH 7.2.
Purity
Purified.
Specificity
Recognizes human KIF2.
Conjugates
Pricing
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