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Anti -LAP2 (Lamina Associated Polypeptide 2, Thymopoietin, TMPO)
Anti -LAP2 (Lamina Associated Polypeptide 2, Thymopoietin, TMPO)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
B |
|
| Catalog # | L1241-01A | | The inner membrane of the nuclear envelope is connected to the nuclear lamina. The main components of the nuclear lamina are Type V intermediate filaments called lamins and lamin binding proteins including lamin B receptor, emerin, MANI, LAP1 (3 isoforms), and LAP2 (several isoforms). The lamins are divided into two groups | the constitutively expressed lamin B and the developmentaly regulated lamin A. | | The best characterized isoforms of lamin binding protein LAP2 are LAP2a and LAP2b. LAP2b is a type II membrane protein in the inner nuclear membrane that binds lamin B and is important to cell viability and controlling nuclear lamina growth. LAP2a has been characterized as a nucleoplasmic protein that interacts with A-type lamins to control gene expression, transcription, and chromatin organization. | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 | | Optimal dilutions to be determined by the researcher. | | Positive Control | A431 cell lysate | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Serum | | Immunogen | His-tagged recombinant protein corresponding to residues surrounding the N-terminus of human LAP2. Cellular Localization: Cell junction › hemidesmosome. | | Specificity | Recognizes the N-terminal region of human LAP2. Recognizes both the alpha and beta isoforms of LAP2 in human samples tested. Species Crossreactivity: mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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