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You are here:Home » Antibodies » Abs to Nuclear Proteins » Anti -LAP2 (Lamina Associated Polypeptide 2, Thymopoietin, TMPO)

Anti -LAP2 (Lamina Associated Polypeptide 2, Thymopoietin, TMPO)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B
Catalog #L1241-01A
The inner membrane of the nuclear envelope is connected to the nuclear lamina. The main components of the nuclear lamina are Type V intermediate filaments called lamins and lamin binding proteins including lamin B receptor, emerin, MANI, LAP1 (3 isoforms), and LAP2 (several isoforms). The lamins are divided into two groups the constitutively expressed lamin B and the developmentaly regulated lamin A.
The best characterized isoforms of lamin binding protein LAP2 are LAP2a and LAP2b. LAP2b is a type II membrane protein in the inner nuclear membrane that binds lamin B and is important to cell viability and controlling nuclear lamina growth. LAP2a has been characterized as a nucleoplasmic protein that interacts with A-type lamins to control gene expression, transcription, and chromatin organization.
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlA431 cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.05% sodium azide.
PuritySerum
ImmunogenHis-tagged recombinant protein corresponding to residues surrounding the N-terminus of human LAP2. Cellular Localization: Cell junction hemidesmosome.
SpecificityRecognizes the N-terminal region of human LAP2. Recognizes both the alpha and beta isoforms of LAP2 in human samples tested. Species Crossreactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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