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L2020-67B Mouse Anti-Leucine-rich alpha-2-glycoprotein (LRG, HMFT1766, Leucine-rich alpha-2-glycoprotein 1, LRG1)

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
P02750
Isotype
IgG1
Clone Number
13A50 (2F5.A2)
Grade
Affinity Purified
Applications
E
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

Leucine-rich alpha-2-glycoprotein (LRG) is a member of the leucine-rich repeat family. LRG is a plasma protein of approximately 50kD. LRG consists of 312aa. It has 1 galactosamine and 4 glucosamine oliogosacharides attached and has 2 intrachain disulfide bonds. Leucine comprises 66 of the 312aa, and LRG contains at least eight 24aa leucine-rich repeats. The consensus of these residues, termed leucine-rich repeats (LRR), has been identified as an LRR-containing domain. The primary function of LRRs is to provide versatile structural framework of the formation of protein-protein interactions. LRG is expressed during granulocyte differentiation. Although several family members of the leucine-rich repeat family have been shown to be involved in signal transduction, protein-protein interaction, or cell adhesion and development, a function for LRG remains elusive. LRG has been reported as a biomarker for certain diseases including microbial infections and cancer. LRG can be detected in human neutrophils and progenitor cells, but not in peripheral blood mononuclear cells.

Applications
Suitable for use in ELISA and Immunopurification of human LRG. Other applications not tested.
Recommended Dilution
ELISA: Antibody was used as detector for LRG on cytochrome C coated plates. Concentration antibody used was 1ug/ml. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Human Leucine-rich alpha-2-glycoprotein, covalently coupled to hemocyanin using glutaraldehyde
Form
Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes human Leucine-rich alpha-2-glycoprotein.
References
1. Weivoda, S et al; ELISA for human serum leucine-rich alpha-2-glycoprotein-1 employing cytochrome c as the capturing ligand. J Immunol Meth 2008, 336: 22. 2. Codina, R et al; Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1. Apoptosis 2010, 15: 139.
USBio References
No references available
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