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You are here:Home » Antibodies » Abs to Carbohydrates, Glycoproteins » Anti -Leucine-rich alpha-2-glycoprotein (LRG, HMFT1766, Leucine-rich alpha-2-glycoprotein 1, LRG1)

Anti -Leucine-rich alpha-2-glycoprotein (LRG, HMFT1766, Leucine-rich alpha-2-glycoprotein
1, LRG1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
Leucine-rich alpha-2-glycoprotein (LRG) is a member of the leucine-rich repeat family. LRG is a plasma protein of approximately 50kD. LRG consists of 312aa. It has 1 galactosamine and 4 glucosamine oliogosacharides attached and has 2 intrachain disulfide bonds. Leucine comprises 66 of the 312aa, and LRG contains at least eight 24aa leucine-rich repeats. The consensus of these residues, termed leucine-rich repeats (LRR), has been identified as an LRR-containing domain. The primary function of LRRs is to provide versatile structural framework of the formation of protein-protein interactions. LRG is expressed during granulocyte differentiation. Although several family members of the leucine-rich repeat family have been shown to be involved in signal transduction, protein-protein interaction, or cell adhesion and development, a function for LRG remains elusive. LRG has been reported as a biomarker for certain diseases including microbial infections and cancer. LRG can be detected in human neutrophils and progenitor cells, but not in peripheral blood mononuclear cells.
Catalog #L2020-67B
ApplicationsSuitable for use in ELISA and Immunopurification of human LRG. Other applications not tested.
Recommended DilutionELISA: Antibody was used as detector for LRG on cytochrome C coated plates. Concentration antibody used was 1ug/ml.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No13A50
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman LRG, covalently coupled to hemocyanin using glutaraldehyde
SpecificityRecognizes human LRG.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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