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L2515-01B Mouse Anti-LPP (Lipoma-preferred Partner, LIM Domain-containing Preferred Translocation Partner in Lipoma)

Specifications
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
Q93052
Isotype
IgG2b
Clone Number
12K127
Grade
Affinity Purified
Applications
WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

Human LIM domain-containing preferred translocation partner in lipoma (LPP) is an 80kD intracellular protein that contains an N-terminal Pro-rich region aa41-370 followed by three tandem LIM domains aa414-603. It localizes to focal adhesion plaques where it regulates junction assembly and cytoskeleton remodeling through interactions with a-Actinin, VASP, SCRIB, Supervillin, and Palladin. In the nucleus, LPP coactivates the transcription factor PEA3 and protects telomeres from DNA damage. LPP is a frequent target of chromosomal translocations with HMG-A2 in lipoma. Within aa138-261, human LPP shares 90% and 77% aa sequence identity with mouse and rat LPP.

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 0.5ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Recombinant corresponding to aa138-261 from human LPP expressed in E.coli.
Form
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
Purity
Purified by Protein A/G affinity chromatography.
Specificity
Recognizes human LPP. Does not react with recombinant human TRIP-4, -6, or -11.
Conjugates
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