Human LIM domain-containing preferred translocation partner in lipoma (LPP) is an 80kD intracellular protein that contains an N-terminal Pro-rich region aa41-370 followed by three tandem LIM domains aa414-603. It localizes to focal adhesion plaques where it regulates junction assembly and cytoskeleton remodeling through interactions with a-Actinin, VASP, SCRIB, Supervillin, and Palladin. In the nucleus, LPP coactivates the transcription factor PEA3 and protects telomeres from DNA damage. LPP is a frequent target of chromosomal translocations with HMG-A2 in lipoma. Within aa138-261, human LPP shares 90% and 77% aa sequence identity with mouse and rat LPP.
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