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You are here:Home » Antibodies » Abs to Cell Markers » Anti -LPAM-1 (Lymphocyte Peyer’s Patch Adhesion Molecule 1, Integrin alpha4,beta7)

Anti -LPAM-1 (Lymphocyte Peyer’s Patch Adhesion Molecule 1, Integrin alpha4,beta7)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified IP IH FC
This antibody is specific for a combinatorial determinate of integrin a4b7complex. Integrin a4b7 is composed of a 150kD (a4 or CD49d) and a 130kD (b7) heterodimer, also known as CD49d/b7, or LPAM-1. It belongs to Ig superfamily found on majority of peripheral lymphocytes and subsets of thymocytes and bone marrow cells (including mast cell progenitors). Integrin a4b7 binds its ligands, VCAM-1 (CD106), MAdCAM-1 and fibronectin, and plays an important role in lymphocytes adhesion and helps direct the migration of blood lymphocytes to the intestine and associated lymphoid tissues. It has been reported that this monoclonal antibody is able to in vitro and in vivo block a4b7 mediated lymphocyte adhesion to VCAM-1, MAdCAM-1 and fibronectin.
Catalog #L3985-05C
ApplicationsSuitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Other applications not tested.
Recommended DilutionFlow Cytometry: 1ug/10e6 cells in 100ul volume
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
HostRat
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenTK1 cells
SpecificityRecognizes mouse LPAM-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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