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Anti -Mast Cell Protease 1 (Mcpt1, Chymase)
Anti -Mast Cell Protease 1 (Mcpt1, Chymase)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Sheep |
Affinity Purified |
B |
|
| Mast cell protease1(Mcpt1), alsoknown as b-c hymase, is a member of the Chymase family of c chymotrypinlike serine proteases (1)mMcpt1is a mast cell protease predominantly expressed in intestinal mucosal mast cells where it promotes mucosal permeabiliy in intestinal allergic hypersensitvity reactions(2). Its activation is completed by the removal of a two residue Ntermi nal propeptide by a dipeptidyl peptidase (Cathepsin C) (3). Like human a-Chymase, Mcpt1 is capable of the conversion of angiotensinI to angiotensin II, which plays a key role in the regulation of arterial pressure (4). Studies have shown that specific chymase inhibitors are able to diminsh the development of abdominal aortic aneurysm and reduce the adhesion formation after cardiac surgery in hamsters (5, 6). Therefore, the development of specific inhibitors of chymase activity has been a pharmacologic strategy to develop therapeutic agents. | | | Catalog # | M2414-01G | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Sheep | | Source | Mouse | | Concentration | Not determined | | Form | Supplied as a lyophilized powder in PBS with Trehalose. Reconstitute with sterile PBS. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant corresponding to mast cell Protease 1/Mcpt1, Glu19Leu246 expressed in NSO cells (P11034). | | Specificity | Recognizes mouse Mast Cell Protease 1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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