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Abs to Matrix Metalloproteinases
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Anti -Matrix Metalloproteinase 7 (MMP-7, Matrilysin, Matrin, Pump1, Uterine Metalloproteinase, MPSL1)
Anti -Matrix Metalloproteinase 7 (MMP-7, Matrilysin, Matrin, Pump1, Uterine
Metalloproteinase, MPSL1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
E B IH |
|
| H-MMP-7 is a member of the Matrix metalloproteinase family of endopeptidases, containing the canonical HExxHxxGxxH motif as a zinc binding active site. MMP-7 and MMP-26 (Matrilysin-2) are the only MMPs discovered that completely lack a hemopexin “regulatory domain” or hinge region. Like the other MMPs, MMP-7 is secreted as a zymogen, then activated. The 28kD form is reduced to 18kD by enzymatic cleavage after the conserved “cysteine switch.” MMP-7 is not constitutively produced. It is produced on demand in specific tissues. MMP-7 substrate specificity is broad, most closely resembling the activity of MMP-3 (Stromelysin-1). When MMP-7 production is stimulated, native MMP inhibitors (TIMPs) usually follow to quench them. | | | Catalog # | M2423-21 | | Applications | | | Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications have not been tested. | | Recommended Dilutions | Western Blot: 10ug/ml. Band at ~30kD | | Immunohistochemistry (Paraffin-embedded tissue sections): 4-20ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Clone Type | Monoclonal | | Isotype | IgG1,k | | Clone No | 2Q524 | | Host | Mouse | | Source | Human | | Concentration | ~2mg/ml | | Form | Supplied as a liquid in PBS, pH 7.0, 2% BSA (protease free) | | Purity | Purified | | Immunogen | Rectal carcinoma (SW837) cells | | Specificity | Recognizes the precursor form of human MMP-7. Does not crossreact with the active form of human MMP-7 or human MMP-1, 2, 3, 8, 9 and 13. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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