double minute 2, human homolog of, OTTHUMP00000183495, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, MGC5370, HDMX, Mdm2 p53 binding protein homolog (mouse), ubiquitin-protein ligase E3 Mdm2, p53-binding protein MDM2, p53-binding protein, mouse double minute 2, human homolog of, mouse double minute 2 homolog, hdm2, MGC71221, HGNC:6973, p53 binding protein (mouse), transformed 3T3 cell double minute 2, Mdm2, MDM2

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.