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You are here:Home » Antibodies » Abs to Ubiquitin » Anti -MDM2 (Murine Double Minute-2)

Anti -MDM2 (Murine Double Minute-2)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IH
MDM2 acts as a major regulator of the tumor suppressor p53 by targeting its destruction. Since the MDM2 gene is frequently amplified in some types of cancers and shows oncogenic activity, it is considered to be an oncogene. Overexpression of MDM2 has been observed in some carcinomas, sarcomas, and leukemias. In breast cancer, MDM2 expression is associated with the tumor grade, and higher MDM2 levels directly correlate with the onset of lymph node metastases and shortened patients survival. In glioblastoma, MDM2 oncogene activation appears to occur late in tumor progression and may be characteristic as a negative prognostic marker.
Catalog #M2800-04
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: Frozen, formalin-fixed paraffin embedded tissue sections. Requires epitope retrieval using EDTA, pH 8.
Optimal dilutions to be determined by the researcher.
Recommended Positive ControlGlioma
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b,k
Clone No4H309
HostMouse
SourceHuman
Concentration~0.15mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
PurityPurified
ImmunogenSynthetic peptide corresponding to the N-terminal region of human MDM2 protein. Cellular Localization: Nucleus.
SpecificityRecognizes human MDM2
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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