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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified IH

MDM2 acts as a major regulator of the tumor suppressor p53 by targeting its destruction. Since the MDM2 gene is frequently amplified in some types of cancers and shows oncogenic activity, it is considered to be an oncogene. Overexpression of MDM2 has been observed in some carcinomas, sarcomas, and leukemias. In breast cancer, MDM2 expression is associated with the tumor grade, and higher MDM2 levels directly correlate with the onset of lymph node metastases and shortened patients survival. In glioblastoma, MDM2 oncogene activation appears to occur late in tumor progression and may be characteristic as a negative prognostic marker.
Catalog #	M2800-04
Applications	Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilutions	Immunohistochemistry: Frozen, formalin-fixed paraffin embedded tissue sections. Requires epitope retrieval using EDTA, pH 8.
	Optimal dilutions to be determined by the researcher.
Recommended Positive Control	Glioma
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG2b,k
Clone No	4H309
Host	Mouse
Source	Human
Concentration	~0.15mg/ml
Form	Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
Purity	Purified
Immunogen	Synthetic peptide corresponding to the N-terminal region of human MDM2 protein. Cellular Localization: Nucleus.
Specificity	Recognizes human MDM2
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.