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You are here:Home » Antibodies » Abs to Ubiquitin Ligases » Anti -Mdm-2, ID (Mdm2, E3 Ubiquitin-protein Ligase Mdm2, Double Minute 2 Protein, p53-binding Protein Mdm2)

Anti -Mdm-2, ID (Mdm2, E3 Ubiquitin-protein Ligase Mdm2, Double Minute 2 Protein,
p53-binding Protein Mdm2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
In mammalian cancer development, transformed 3T3 cell double minute 2 homolog (mouse) (mdm2) is the main negative regulator of p53. Tumorigenesis likely involves mdm2 in the inactivation of the p53 tumor suppression pathway. A double knockdown study of p53 and mdm2 reiterated the validity of the zebrafish model for characterizing future cancer treatments due to similarities with the mammalian p53 pathway. One study led to production of a transgenic zebrafish strain characterized by overproduction of mdm2 in liver tissue. This strain may be a model for studying the effects of compounds on mdm2 related pathways.
Catalog #M2800-10
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Western Blot: 1:500-1:1000
Immunohistochemistry: 1:200
Optimal dilutions to be determined by the researcher.
Control Peptide M2800-10P
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceZebrafish
ConcentrationNot determined
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the intermediate region of zebrafish Mdm-2.
SpecificityRecognizes zebrafish Mdm-2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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