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You are here:Home » Molecular Biology » MB-Protein Kinase Inhibitors » MEK1 Inhibitor (PD98059, 2-amino-3- methoxyflavone)

MEK1 Inhibitor (PD98059, 2-amino-3- methoxyflavone)


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PD98059 is a potent and selective cell permeable inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK, thereby inhibiting the phosphorylation and the activation of MAP kinase. In pheochromocytoma (PC12) cells, it completely blocks the increase in MAP kinase activity produced by NGF. PD98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems.
Catalog #M2865-17B
Molecular Weight~267.3
Biological ActivityIC50=2uM
SolubilityDMSO (~6.5mg/ml), anhydrous DMSO (~25mg/ml), ethanol (~0.6mg/ml). It is recommended that this compound be diluted directly from the DMSO stock into buffered media with stirring. Please note that bovine serum albumin at a concentration of 6.6mg/ml has been observed to prevent the precipitation of PD98059 in aqueous media.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number167869-21-8
Molecular FormulaC16H13NO3
Molecular Weight267.3
Purity~95% (HPLC)
ConcentrationNot determined
FormSupplied as a pale yellow lyophilized powder. Reconstitute with sterile dH2O to 0.1-1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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