MEK1 Inhibitor CAS 167869-21-8

CAS Number

167869-21-8

Grade

Highly Purified

Molecular Formula

C16H13NO3

Molecular Weight

267.3

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

PD98059 is a potent and selective cell permeable inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK, thereby inhibiting the phosphorylation and the activation of MAP kinase. In pheochromocytoma (PC12) cells, it completely blocks the increase in MAP kinase activity produced by NGF. PD98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems.

Molecular Weight

~267.3

Biological Activity

IC50=2uM

Solubility

DMSO (~6.5mg/ml), anhydrous DMSO (~25mg/ml), ethanol (~0.6mg/ml). It is recommended that this compound be diluted directly from the DMSO stock into buffered media with stirring. Please note that bovine serum albumin at a concentration of 6.6mg/ml has been observed to prevent the precipitation of PD98059 in aqueous media.

Storage and Stability

Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Purity

~95% (HPLC)

Concentration

Not determined

Form

Supplied as a pale yellow powder.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Alessi, D.R., et al. (1995) J. Biol. Chem. 270(46):27489-27494 2. Pang, L., et al. (1995). J. Biol. Chem. 270(23):13585-13588. 3. Romerio, F. and D. Zella (2002). FASEB J. 16(12):1680-1682. 4. Yeh, P.Y., et al. (2002) Biochem. Pharmacol. 63(8):1423-1430. 5. Wang, X. and G.P. Studzinski (2001) Exp. Cell. Res. 268(2):294-300

USBio References

No references available

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M2865-17B MEK1 Inhibitor (PD98059, 2’-amino-3’- methoxyflavone) CAS: 167869-21-8

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