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M2865-17B MEK1 Inhibitor (PD98059, 2’-amino-3’- methoxyflavone) CAS: 167869-21-8

Specifications
References
CAS Number
167869-21-8
Grade
Highly Purified
Molecular Formula
C16H13NO3
Molecular Weight
267.3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

PD98059 is a potent and selective cell permeable inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK, thereby inhibiting the phosphorylation and the activation of MAP kinase. In pheochromocytoma (PC12) cells, it completely blocks the increase in MAP kinase activity produced by NGF. PD98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems.

Molecular Weight
~267.3
Biological Activity
IC50=2uM
Solubility
DMSO (~6.5mg/ml), anhydrous DMSO (~25mg/ml), ethanol (~0.6mg/ml). It is recommended that this compound be diluted directly from the DMSO stock into buffered media with stirring. Please note that bovine serum albumin at a concentration of 6.6mg/ml has been observed to prevent the precipitation of PD98059 in aqueous media.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~95% (HPLC)
Concentration
Not determined
Form
Supplied as a pale yellow powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Alessi, D.R., et al. (1995) J. Biol. Chem. 270(46):27489-27494 2. Pang, L., et al. (1995). J. Biol. Chem. 270(23):13585-13588. 3. Romerio, F. and D. Zella (2002). FASEB J. 16(12):1680-1682. 4. Yeh, P.Y., et al. (2002) Biochem. Pharmacol. 63(8):1423-1430. 5. Wang, X. and G.P. Studzinski (2001) Exp. Cell. Res. 268(2):294-300
USBio References
No references available
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