PD98059 is a potent and selective cell permeable inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK, thereby inhibiting the phosphorylation and the activation of MAP kinase. In pheochromocytoma (PC12) cells, it completely blocks the increase in MAP kinase activity produced by NGF. PD98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems.
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