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You are here:Home » Molecular Biology » MB-Protein Kinase Inhibitors » MEK1 Inhibitor (PD98059, 2-amino-3-methoxyflavone)

MEK1 Inhibitor (PD98059, 2-amino-3-methoxyflavone)


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Potent, selective and cell-permeable inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK kinase). Inhibits phosphorylation of MAP kinase by MAP kinase kinase. PD 98059 does not inhibit MAP kinase itself. IC50 values for PD 98059-induced effects are in the 1-20uM range for many assays; it is somewhat weaker in inhibiting cell growth in monolayers or agar for some cell lines.
Catalog #M2865-17C
SolubilitySoluble in DMSO.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number167869-21-8
Molecular FormulaC16H13NO3
Molecular Weight267.28
FormSupplied as a pale yellow powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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