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M2865-17C MEK1 Inhibitor (PD98059, 2’-amino-3’-methoxyflavone) CAS: 167869-21-8

Specifications
References
CAS Number
167869-21-8
Grade
Highly Purified
Molecular Formula
C16H13NO3
Molecular Weight
267.28
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Potent, selective and cell-permeable inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK kinase). Inhibits phosphorylation of MAP kinase by MAP kinase kinase. PD 98059 does not inhibit MAP kinase itself. IC50 values for PD 98059-induced effects are in the 1-20uM range for many assays; it is somewhat weaker in inhibiting cell growth in monolayers or agar for some cell lines.

Solubility
Soluble in DMSO.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~99%
Form
Supplied as a pale yellow powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Dudley, D.T., et al. "A synthetic inhibitor of the mitogen-activated protein kinase cascade." "Proc. Natl. Acad. Sci. USA 92:7686-7689 (1995). 2. Pang, L., et al. "Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor." J. Biol. Chem. 270:13585-13588 (1995). 3. Waters, S.B., et al. "Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex." J. Biol. Chem. 270:20883-20886 (1995). 4. Langlois, W.J., et al. "Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation." J. Biol. Chem. 270:25320-25323 (1995). 5. Alessi, D.R., et al. "PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo." J. Biol. Chem. 270:27489-27494 (1995).
USBio References
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