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M3410-01C Rabbit Anti-Methylene Tetrahydrofolate Dehydrogenase 2, CT (MTHFD2, Bifunctional Methylenetetrahydrofolate Dehydrogenase/cyclohydrolase Mitochondrial, NADP+ Dependent Methylenetetrahydrofolate Dehydrogenase 2 Methenyltetrahydrofolate Cyclohydrolase, NMDMC)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P13995
Isotype
IgG
Grade
Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_006627
Shipping Temp
Blue Ice
Storage Temp
-20°C
Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase, Methenyltetrahydrofolate Cyclohydrolase, EC=3.5.4.9, |NAD-dependent Methylenetetrahydrofolate Dehydrogenase, EC=1.5.1.15

MTHFD2 is a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:50-1:100 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide selected from the C-terminal region of human MTHFD2 (KLH).
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human MTHFD2.
References
1. Wang,S.S., Leukemia 23(3), 596-602 (2009). 2. Pawelek,P.D., Biochemistry 37(4), 1109-1115 (1998).
USBio References
No references available
Conjugates
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