(6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-methylmilbemycin B; |Spiro[11,15-methano-2H,7H,13H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2’-[2H]pyran], milbemycin B deriv.; (+)-Milbemycin α1; Antibiotic B 41A3; Emamectin A3; GWN 1725; Gowan 1725; Koromite; Matsuguard; Mesa; Mesa (acaricide); Milbeknock; Milbemectin; Milbemycin A3; Milbemycin α1; Ultiflora; Milbemycin EP Impurity B

Milbemycins are a complex family of macrocyclic lactones containing a highly characteristic spiroketal group produced by Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycin A3 is the dominant member of a group of analogues containing a 25-methyl substituent. Milbemycin A3 is a highly selective and potent nematocide and insecticide. Like the closely related avermectins, milbemycins are thought to act on chloride-gated ion channels. Related to: Avermectin B1a, Avermectin B1b, Milbemycin A4, Milbemycin D, Nemadectin.